In organism body (individual level) always any
regulation mechanism for achieve
situation which homeostatic. Homeostatic is effort to defending or making
condition which steady state which assure of optimization all process of
physiology in body. For achieve this situation, body doing many regulation
activity, as mechanism to achieve the homeostatic which be provided. Regulation
and homeostatic which happen in big organism level, that are in population
level and community in a ecosystem.
Regulation system have function to manage a work in all of organ system which
any in the human body. Regulation system is work to accept the stimulation,
processing the stimulation and receive the stimulation. (Rikky Firmansyah, 2009: 129)
All of system in organism body play along with the
other for defending the homeostatic in our body. Homeostasis as need by cell and tissues of our body to can work
very well to confronted the external environment change. Some homeostatic
mechanism which important, that are: thermoregulation, osmoregulation, water and electrolit regulation and
glucoregulation. In human body,
the regulation be done by nerve and hormon. (Tati suryati syamsudin Subahar, 2009:
67)
When any change in our body, any 2 respond mechanism
which happen possible, that are:
1.
Negative
feedback
A process which happen when our body
system need stoping according to
complete a process which was happening.
The example when the blood pressure
increase, receptor in artery carotid will be detecting and sending signal to
the brain. The brain will send message to heart to decelerate the throb so the
blood current which pumped more little and cause decrease of blood pressure.
2.
Positive
Feedback
A respond to make a process
physiologist or action from a system. Usually this respond is a siklik process
which can be continue to consolidate a action or a process until respond of
negative feedback take change position. (Rikky Firmansyah, 2009: 131)
The example of regulation process is thermoregulation.
Thermoregulation is a physiological process that is the integration and coordination
of activities that are actively used to maintain core body temperature against
cold or warm temperature changes. Human is homeothermik creature which can
manage a body temperature for achieve a equilibrium so body temperature
disposed constant which not influence by environment temperature. Human enzim
work effective in 370 C temperature. Center of temperature manage in
brain part of hypothalamus. There are some effector which engage between
variation mammals. Temperature managed with some mechanism. Fluctuation
temperature detected by receptor which called thermoreceptor, the example is
skin.
If we very hot or cold because influence from out
environment or in our body, so thermoreceptor will be send nerve impuls to
hypothalamus. After that hypothalamus will be send message response to effector
like skin to increase or decrease the lose of heat from surface with:
a.
Increase body
temperature responded with stand hair feather (pyloerection) because
contraction skin muscles whereas decrease body temperature responded with
restraint body heat with flat the feather hair because skin muscle relaction.
b.
Glands under
skin will be secretion sweat to skin surface for increasing the lose of heat
with evaporation if temperature body increasing. Secretion of sweat will stop
if body temperature have been comeback normal.
c.
Blood vessel
which currrent skin will broad for bring a more some heat out from body
(vasodilatation) if body temperature increase, and blood vessel will shrink
(vasoconstriction) to minimalition loosing of heat through skin if body
temperature have been normal again.
If happen
decrease long temperature, so hypothalamus will be increasing the secretion of
hormon TRH to stimulate output TSH by hypophysis which will be stimulate
increase secretion hormon tyrocsin by thyroid gland. This hormon will impedance
metabolism which have other product heat energy. Other that, non specific
mechanism to bridge decrease body temperature is with contraction of muscles
extremity for producting of heat.
In the regulation of body
temperature, the animal must regulate heat received or are lost to the
environment. Mechanism changes the animal's body heat can occur with 4
processes, namely conduction, convection, radiation and evaporation. Conduction
is the change in the animal's body heat due to contact with an object.
Convection is heat transfer due to the movement of air or fluids through the
body surface. Radiation is the emission of electromagnetic energy. Radiation
can transfer heat between objects that are not in direct contact. For example,
solar radiation. Evaporation heat loss from the surface of the liquid is
transformed in the form of gas.
The
hypothalamus is a very sensitive part, which is the main integration center to
maintain energy balance and body temperature. The hypothalamus serves as the
body's thermostat, to receive information from various parts of the body in the
skin. Coordinated with the adjustment mechanism is very complicated in addition
and subtraction as appropriate temperatures for core temperature any deviation from the normal reference values. The hypothalamus is able to
respond to changes in blood temperature as small as 0.01 º C.
The
hypothalamus constantly informed of skin temperature and core temperature
through specific receptors that are sensitive to temperature called
thermoreseptor (receptor warm, cold and pain in the periphery). Temperature
receptors are very active during temperature changes. Primary temperature
sensation adapted very quickly. Core temperature is monitored by a central
termoreseptor located in the hypothalamus and in the central nervous system and
abdominal organs.
In
the center of the hypothalamus known to have 2 temperature settings, ie in the
posterior region and anteror. Posterior region is activated by cold
temperatures and then trigger the reflex that mediates heat production and heat
conservation. Moderate, anterior region that is activated by a sense of warmth,
triggering a reflex that mediates heat reduction.
Thermoregulation
in Humans
Human
thermoregulation centered on the anterior hypothalamus, there are three
components making up the system controller or heat settings, namely
thermoreseptor, hypothalamus, and efferent nerves and thermoregulation can
maintain body temperature, the temperature-specific constant temperature is
usually higher than the surrounding environment.
Body
temperature regulation mechanism is a combination of the functions of organs
interconnected. regulation of body temperature in mammals, there are two types
of temperature control sensors, heat sensors and sensor is cool different
places on the network around (outside receivers) and core network (receiver
inside) of body. From both types of sensors, the signals received directly
transmitted to the central nervous system and then sent to the motor neurons
that regulate heat expenditure and heat production to proceed to the heart, the
lungs and the whole body.
Once
that happens the feedback, which signals, received back by the sensor heat and
cold sensors through the bloodstream.
Most heat is lost through the process
of radiation, the sweat cooling off. Through evaporation serves to keep the
body temperature to remain constant. and modification of the circulatory system
in the skin. Contrition blood vessels in the skin and countercurrent heat
exchange is one way to reduce the loss of body heat. Human wearing is one of
the unique behavior in thermoregulation.
Human body temperature tends to
fluctuate at any time. Many factors could cause fluctuations in body temperature.
To maintain the temperature of the human body in a state of constant, necessary
regulation of body temperature. Human body temperature regulated by a feedback
mechanism (feed back), played by temperature regulation center in the
hypothalamus. If the temperature of the center of the hypothalamus detects body
temperature is too hot, the body will conduct a feedback mechanism. This
feedback mechanism occurs when the core body temperature has been over the
limit of tolerance for maintaining body temperature, which is called a fixed
point (set point). Fixed point so that the body is maintained at a constant
core body temperature of 37 ° C. when the body temperature rises over a fixed
point, the hypothalamus will be stimulated to undertake a series of mechanisms
to maintain temperature by reducing heat production and increase the heat so
that the temperature back spending on fixed point.
Our bodies are equipped with various
advanced system settings, including the regulation of body temperature. Humans
have the central regulation of body temperature (thermostat), located in the
part of the brain called the hypothalamus. The body temperature regulation
center peg our body temperature at one point called the set point.
The hypothalamus duty to always
maintain a constant body temperature, ranging at 37 ° C. That's why, wherever
humans are, at the poles or in the desert, the body temperature stable should
always be pursued, so that the man referred to as being able to adapt.
Hypothalamic thermostat works on intake of nerve endings and the temperature of
the blood circulating in the body. Hypothalamus in the cold will make the
program so that the body is not cold, by raising the set point alias raise body
temperature. How to contract the blood vessels, body shiver and look pale.
While in the hot air, of course, must
hypothalamus lowers body temperature to prevent heatstroke. You do this by
removing heat through evaporation. Blood vessels dilate, breathing becomes more
rapid. Therefore, at the time of the heat, in addition to sweating, we also
looked reddish skin (flushing).
Organ Regulatory Body Temperature:
- Heat regulating center in the body is the
hypothalamus, the hypothalamus known as the thermostat is located under the
brain.
- Anterior hypothalamus regulates heat dissipation
- Posterior hypothalamus regulates heat
retention efforts
- Mechanism of temperature regulation
- Skin -> Receptor ferifer ->
hypothalamus (posterior and anterior) -> Preoptica hypotalamus -> Nerve
efferent -> loss / heat generation
Factors
Affecting Body Temperature
1.
Basal metabolic rate
Basal
metabolic rate of each individual is different. It impacts the amount of heat
produced by the body to be different. As mentioned in the previous description,
it is related to the rate of metabolism.
2.
Sympathetic nerve stimulation
Sympathetic
nerve stimulation can cause the metabolic rate to 100% faster. In addition,
sympathetic nerve stimulation can prevent brown fat that accumulate in tissues
to be metabolized. Almost all brown fat metabolism is the production of heat.
Generally, the sympathetic nerve stimulation affected individuals stress causes
increased production of epinephrine and norepineprin that increase metabolism.
3.
Growth hormone
Growth hormone (growth hormone) may
cause an increase in metabolic rate by 15-20%. As a result, the body's heat
production also increased.
4.
Thyroid hormone
Function
of thyroxine is increased activity of almost all chemical reactions in the body
so that the increased levels of thyroxine can affect the rate of metabolism to
be 50-100% higher than normal.
5.
Sex hormone
Male
sex hormones can increase the basal metabolic rate of approximately 10-15%
normal speed, causing an increase in heat production. In women, temperature
fluctuations are more varied than in men because the hormone progesterone
spending to ovulation increases body temperature approximately from 0.3 to 0.6
° C above the basal temperature.
6.
Fever (inflammation)
The
process of inflammation and fever may lead to increased metabolism by 120% for
each increase in temperature of 10 ° C
7. Nutritional status
Malnutrition
is long enough to lower the metabolic rate of 20-30%. This happens because the
cells no nutrients needed to conduct metabolism. Thus, people who are prone to
mal nutrition drop in body temperature (hypothermia). In addition, individuals
with a thick layer of fat are less likely to develop hypothermia because fat is
a pretty good insulator, in the sense of delivering hot fat with the speed of
the other one-third the speed of the network.
8. Activity
Activity
in addition to stimulating an increase in metabolic rate, resulting in friction
between the components of the muscle / organ that produces thermal energy.
Exercise (activity) can increase body temperature up to 38.3 to 40.0 ° C.
9.
Organ disorders
Organ
damage such as trauma or malignancy in the hypothalamus, can cause the body's
temperature regulation mechanisms impaired. Pyrogen substances released on infection can stimulate an increase in body temperature. Skin disorders such as
number of sweat glands which can also lead to impaired body temperature
regulation mechanism.
10.Environment
The
body temperature can rapidly exchange with the environment, meaning that the
body heat can be lost or impaired due to a cooler environment. Vice versa, the
environment can affect the temperature of the human body. Temperature
displacement between humans and the environment occur mostly through the skin.
Thermoregulation in
Animals
Animals
have the ability to adapt to changes in environmental temperature. For example,
in cold temperatures, mammals and birds will increase the rate of metabolism by
changes in hormones that are involved in it, thereby increasing heat
production. At ektoterm (eg, the honey bee), adaptation to cold temperatures by
groups in the nest. The metabolism of bees as a group capable of generating
heat in the nest.
Some
animal adaptations to reduce heat loss, such as the fur and hair in birds and
mammals, muscles, and modification of the circulatory system in the skin. Contriksi blood vessels in the skin and countercurrent heat exchange is one way
to reduce the loss of body heat. Behavior is important in relation to
thermoregulation. Migration, relocation, and was found hiding in some animals
to lower or raise the body temperature. Elephants in the tropics to lower body
temperature by bathing or wag earlobe to the body. Humans use apparel is one of
the unique behavior in thermoregulation.